Lihlahisoa
2,4-Diamino-6-hydroxypyrimidine 2,6-Diamino-4-Hydroxyprimidine
Synonyms: 4 (1H) -Pyrimidinone,2,6-diamino- (8CI,9CI);2,4-Diamino-6-hydroxypyrimidine;2,4-Diamino-6-pyrimidinone;2,6-Diamino-3,4 -dihydropyrimidin-4-one;2,6-Diamino-4 (1H) -pyrimidinone;2,6-Diamino-4 (3H) -pyrimidinone;2,6-Diamino-4-hydroxypyrimidine;2,6-Diamino-4 -pyrimidinol;2,6-Diaminopyrimidin-4-one;2,6-Diaminopyrimidine-4 (3H)-e le ’ngoe;6-Aminoisocytosine;6-Hydroxy-2,4-pyrimidinediamine;NSC 44914;NSC 680818;NSC9302;
Thepa ea lik'hemik'hale ea 2,4-Diamino-6-hydroxypyrimidine
● Ponahalo/Mmala: bosoeu bo tiileng
● Khatello ea Mouoane: 0.00232mmHg ho 25°C
● Sebaka se qhibilihang: 285-286 °C (dec.)(lit.)
● Refractive Index:1.7990 (khakanyo)
● Ntho e Belang: 288.5 °C ho 760 mmHg
● PKA:10.61±0.50(E boletsoeng esale pele)
● Flash Point: 128.3 °C
● PSA: 98.05000
● Boima ba 'mele: 1,84 g/cm3
● LogP: 0.50900
● Mocheso oa ho Boloka.: Fokotsa ho +4°C
● E na le Kutloelo-bohloko.: Khanya e Kutloha
● Solubility.:DMSO (Hanyenyane), Methanol (Hanyenyane)
Bohloeki/ Boleng
99% * data ho tsoa ho barekisi ba sa sebetseng
2,4-Diamino-6-hydroxypyrimidine *data ho tsoa ho bafani ba reagent
Boitsebiso bo Boreleli
● Litšoantšo:
Xi
● Likhoutu tsa Kotsi:Xi
● Lipolelo:36/37/38
● Lipolelo tsa Tšireletseho: 22-24/25-36-26
Lifaele tsa MSDS
E molemo
● Tlhaloso: 2,4-Diamino-6-hydroxypyrimidine (DAHP) ke inhibitor e khethehileng, e khethehileng ea GTP cyclohydrolase I, mohato o fokolang oa tekanyo ea de novo pterin synthesis.Liseleng tsa HUVEC, IC50 bakeng sa thibelo ea BH4 biosynthesis e ka ba 0.3 mM.DAHP e ka sebelisoa ho thibela ka katleho tlhahiso ea NO mefuteng e mengata ea lisele.
● Lisebelisoa: 2,4-Diamino-6-hydroxypyrimidine (DAHP) ke inhibitor e khethehileng, e khethehileng ea GTP cyclohydrolase I, mohato o fokotsang tekanyo ea de novo pterin synthesis.Liseleng tsa HUVEC, IC50 bakeng sa thibelo ea BH4 biosynthesis e ka ba 0.3 mM.DAHP e ka sebelisoa ho thibela ka katleho tlhahiso ea NO mefuteng e mengata ea lisele.[Cayman Chemical] E eme qalong ea enzyme-catalyzed cascade e qalang ka lik'habohaedreite tsa carbon tse supileng 'me e qetella ka li-amino acid tse nkhang hamonate phenylalanine, tyrosine, le tryptophan. 2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) ke motsoako o sebetsang ho organic synthesis.
2,4-Diamino-6-hydroxypyrimidine ke motsoako oa lik'hemik'hale o nang le mokhoa oa molek'hule oa C4H6N4O.Hangata e sebelisoa e le setsi sa ho kopanya metsoako e sa tšoaneng, ho kenyelletsa le lithethefatsi tsa meriana le li-dyes.Motsoako o na le mohaho oa lesale oa pyrimidine o nang le lihlopha tse peli tsa amino (NH2) le sehlopha se le seng sa hydroxyl (OH) se kopantsoeng le liathomo tse fapaneng tsa carbon.Sebopeho sena se etsa hore e be mohaho o nang le mekhoa e metle bakeng sa ho qaptjoa ha limolek'hule tse rarahaneng haholoanyane.2,4-Diamino-6-hydroxypyrimidine e ka fumanoa ka mekhoa e sa tšoaneng ea maiketsetso, ho kenyelletsa le karabelo ea cyanamide ka urea.E na le likopo tse 'maloa indastering ea meriana, haholo-holo ha ho etsoa lithethefatsi tsa anticancer le lithibela-mafu.Ka kakaretso, 2,4-Diamino-6-hydroxypyrimidine ke motsoako oa bohlokoa o fumanang tšebeliso ea lik'hemik'hale tse fapaneng tsa lik'hemik'hale le tsa meriana.
