Lihlahisoa
2,4-Diamino-6-hydroxypyrimidine
Lintho tsa Lik'hemik'hale tsa Hydroxypyrimidine
| Sebaka se qhibilihang | 285-286 °C (Dec.) (hote.) |
| Ntho e belang | 234.22°C (khakanyo e boima) |
| tekano | 1.3659 (khakanyo e fosahetseng) |
| index ea refractive | 1.7990 (khakanyo) |
| mocheso oa polokelo. | Lula sebakeng se lefifi, sepakapaka se se nang moea, mocheso oa kamore |
| ho qhibiliha | DMSO (Hanyane), Methanol (Hanyenyane) |
| pka | 10.61±0.50(E boletsoeng esale pele) |
| sebopeho | Phofo e Ntle ea Crystalline |
| mmala | E tšoeu ho ea ho tranelate |
| E hloahloa | Khanya e Imamela |
| Merck | 14,2981 |
| BRN | 125006 |
| InChIKey | SWELIMKTDYHAOY-UHFFFAOYSA-N |
| Referense ea CAS DataBase | 56-06-4(CAS DataBase Reference) |
| Referense ea Khemistri ea NIST | 4(1H) -pyrimidinone, 2,6-diamino-(56-06-4) |
| EPA Substance Registry System | 2,6-Diamino-4(1H)-pyrimidinone (56-06-4) |
Hydroxypyrimidine Tlhaloso ea Sehlahisoa
2,4-Diamino-6-hydroxypyrimidine ke motsoako oa lik'hemik'hale o nang le mokhoa oa molek'hule oa C4H6N4O.Ke motsoako oa manyolo oa lelapa la pyrimidine.Motsoako o na le sebopeho sa lesale la pyrimidine, lihlopha tse peli tsa amino (NH2) li kopantsoe sebakeng sa 2-position le 4-position, 'me sehlopha sa hydroxyl (OH) se kopantsoe sebakeng sa 6.Sebopeho sa lik'hemik'hale se ka hlalosoa e le: Ammonia ||H--C--C--C--N--C--C--NH2 || oh 2,4-Diamino-6-hydroxypyrimidine e na le lisebelisoa tse sa tšoaneng indastering ea meriana.Ke karolo ea bohlokoa ea ho kopanya lithethefatsi tse ngata, ho kenyelletsa le li-antiviral le antitumor.E boetse e sebelisoa ho hlahisa li-nucleotide analogues tse sebelisoang lipatlisisong tsa meriana.
Ntle le lisebelisoa tsa meriana, 2,4-diamino-6-hydroxypyrimidine e boetse e sebelisoa e le motsoako oa lik'hemik'hale tsa agrochemicals.Ke motsoako o ka sehloohong oa ho kopanya lilaoli tsa kholo ea limela le li-fungicides.Ke habohlokoa haholo ho latela mokhoa o nepahetseng oa tšireletso ha u sebelisa 2,4-diamino-6-hydroxypyrimidine.Kaha e hlalosoa e le ntho e halefisang lik'hemik'hale, e lokela ho tšoaroa ka hloko 'me ho lokela ho apesoa thepa e lekaneng ea ho itšireletsa ho qoba ho kopana ka ho toba.
Ka kakaretso, 2,4-diamino-6-hydroxypyrimidine ke motsoako oa manyolo o nang le likopo masimong a meriana le a temo.Sebopeho sa eona sa lik'hemik'hale se etsa hore e be molemo e le karolo e bohareng ea motsoako oa meriana le balaoli ba kholo ea limela.
Boitsebiso ba Tšireletseho
| Likhoutu tsa Kotsi | Xi |
| Lipolelo tsa Kotsi | 36/37/38 |
| Lipolelo tsa Tšireletseho | 22-24/25-36-26 |
| WGK Jeremane | 3 |
| Tsebiso ea Kotsi | E tenang |
| TSCA | Ee |
| Khoutu ea HS | 29335995 |
Tšebeliso ea Hydroxypyrimidine le Synthesis
| Tlhaloso | 2,4-Diamino-6-hydroxypyrimidine (DAHP) ke inhibitor e khethehileng, e khethehileng ea GTP cyclohydrolase I, mohato o fokolang oa tekanyo ea de novo pterin synthesis.Ka liseleng tsa HUVEC, IC50bakeng sa ho thibela BH4biosynthesis e ka bang 0.3 mmM.DAHP e ka sebelisoa ho thibela ka katleho tlhahiso ea NO mefuteng e mengata ea lisele. |
| Lintho tsa Lik'hemik'hale | White Tiileng |
| Lisebelisoa | 2,4-Diamino-6-hydroxypyrimidine (DAHP) ke inhibitor e khethehileng, e khethehileng ea GTP cyclohydrolase I, mohato o fokolang oa tekanyo ea de novo pterin synthesis.Liseleng tsa HUVEC, IC50 bakeng sa thibelo ea BH4 biosynthesis e ka ba 0.3 mM.DAHP e ka sebelisoa ho thibela ka nepo tlhahiso ea NO mefuteng e mengata ea lisele.[Cayman Chemical] |
| Lisebelisoa | E eme qalong ea enzyme-catalyzed cascade e qalang ka k'habone ea khabone e supileng 'me e qetella ka li-amino acid tse nkhang hamonate phenylalanine, tyrosine, le tryptophan. |
| Lisebelisoa | 2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) ke motsoako o sebetsang ho organic synthesis. |
| Mekhoa ea ho Hloekisa | E nchafatsa ho tloha ho H2O.[Beilstein 25 III/IV 3642.] |
