Di-tert-butyl dicarbonate

Tlhaloso e Khutšoanyane:

Lebitso la Sehlahisoa:Di-tert-butyl dicarbonate

Mantsoe a tšoanang:(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;tert-butyldicarbonate;PYROCARBONIC ACID DI-TERT-BUTYL ESTER;RARECHEM TB OC 0001;Boc Anhydride, e tiileng/mokelikeli

CAS:24424-99-5

MF:C10H18O5

MW:218.25

EINECS:246-240-1

Lihlopha tsa lihlahisoa:Bohareng ba Meriana;Ho qala Lisebelisoa tse tala le tse ka hare; Li-Amino Acid Derivatives;Organics;N-Protecting Reagents;Biochemistry;Peptide Synthesis;Tsireletso & Derivatization Reagents (bakeng sa Synthesis); Lisebelisoa tse Sireletsang (Peptide Synthesis);Reagents bakeng sa Synthesis ea Oligosa; Letoto la li-amino acid tsa Boc-Amino;Mesebetsi e Menyenyane;DIBOC;1H-Inden-1-ol;bc0001;24424-99-5

Mol File:24424-99-5.mol

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Di-tert-butyl dicarbonate Chemical Properties

Sebaka se qhibilihang	23 °C (hote.)
Ntho e belang	56-57 °C/0.5 mmHg (lit.)
tekano	0.95 g/mL ho 25 °C (hote.)
khatello ea mouoane	3.85Pa ho 25 ℃
index ea refractive	n20/D 1.409(lit.)
Fp	99 °F
mocheso oa polokelo.	2-8°C
sebopeho	Crystalline e tsitsitseng e tlase
mmala	Bosoeu
Matla a Khoheli a khethehileng	0.950
Ho qhibiliha ha Metsi	E kopantsoe le decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile le dimethylformamide.E sa kopane le metsi.
E hloahloa	E Mamela Mongobo
BRN	1911173
InChIKey	DYHSDKLCOJIUFX-UHFFFAOYSA-N
LogP	1.87 ho 25 ℃
Referense ea CAS DataBase	24424-99-5(CAS DataBase Reference)
EPA Substance Registry System	Dicarbonic acid, bis(1,1-dimethylethyl) ester (24424-99-5)

Boitsebiso ba Tšireletseho

Likhoutu tsa Kotsi	T+,T,F,Xi,F+
Lipolelo tsa Kotsi	11-19-26-36/37/38-43-10-40
Lipolelo tsa Tšireletseho	16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
RIDADR	UN 2929 6.1/PG 1
WGK Jeremane	3
RTECS	HT0230000
F	4.4-10-21
Autoignition Mocheso	460 °C
Tsebiso ea Kotsi	E tukang mollo/E halefisang/E Chefo Haholo
TSCA	Ee
HazardClass	6.1
Sehlopha sa Packing	I
Khoutu ea HS	29209010
Chefo	LD50 ka molomo ho Mmutla: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

Tšebeliso ea Di-tert-butyl dicarbonate le Synthesis

Lintho tsa Lik'hemik'hale	Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) ke likristale tse se nang 'mala ho isa ho tse tšoeu ho isa ho tse mosehla, boima bo tiileng kapa mokelikeli o hlakileng.E qhibiliha ho pota mocheso oa kamore (mp=23°C).Ha e bole sebakeng sena kapa esita le mocheso o phahameng hanyane.Mohlala, hangata e hloekisoa ka ho tšeloa tlas'a khatello e fokotsehileng mochesong o fihlang ho 65°C.Ha lithempereichara tse holimo li tla bola ho ba isobutene, joala ba t-butyl le carbon dioxide.
Lisebelisoa	Di-tert-butyl dicarbonate (Boc2O) ke sesebelisoa se sebelisoang haholo ho hlahisa lihlopha tse sireletsang ka har'a peptide synthesis.E phetha karolo ea bohlokoa ho lokiseng 6-acetyl-1,2,3,4-tetrahydropyridine ka ho itšoara ka 2-piperidone.E sebetsa e le sehlopha se sireletsang se sebelisoang molemong oa ho kopanya peptide e tiileng.
Tokisetso	Ho lokisoa ha Di-tert-butyl dicarbonate ke ka tsela e latelang: Ho motsoako oa letsoai oa sodium monoester o ile oa eketsoa 2g ea N, N-dimethylformamide, 1g ea pyridine, 1g ea triethylamine, Pholiso ho -5 ~ 0 ° C, 60g diphosgene e ne e le butle-butle. e kenyellelitsoe ho theoha ka har'a 1.5h dropwise keketso e phethiloe, e futhumetse mocheso oa kamore (25 ° C), e kenngoa bakeng sa 2h, karabelo e ile ea lumelloa ho ema ka mor'a ho sefa, ho hlatsoa tharollo ea organic.E omisitsoe ka anhydrous magnesium sulfate, solvent e ile ea ntšoa ka khatello ea sepakapaka ho fana ka sehlahisoa se tala 65 ~ 70g.Ka mor'a ho pholile le ho kristale, 57-60g ea di-tert-butyl dicarbonate e ile ea fumanoa ka lihlahisoa tsa 60-63%.
Tlhaloso	ChEBI: Di-tert-butyl dicarbonate ke acyclic carboxylic anhydride.E sebetsa e amana le dicarbonic acid.
Boitšoaro	Boitšoaro ba li-aniline tse nketsoeng sebaka le Boc2O ka boteng ba palo ea stoichiometric ea 4-dimethylaminopyridine (DMAP) ka har'a motsoako o sa sebetseng (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) mocheso oa kamore o lebisa ho aryl isocyanates hoo e batlang e le ka bongata ba 10. min. Di-tert-butyl dicarbonate le 4-(dimethylamino)pyridine li hlahlobiloe hape.Boitšoaro ba bona ka li-amine le lino tse tahang
Tlhaloso e Akaretsang	Di-tert- butyl dicarbonate (Boc₂O) ke reagent e sebelisoang haholo ho kenyelletsa sehlopha sa ts'ireletso sa Boc ho amine functionalities.E boetse e sebelisoa e le ntho e senyang metsi ka har'a lintho tse ling tsa tlhaho, haholo-holo ka li-carboxylic acid, lihlopha tse itseng tsa hydroxyl, kapa ka li-nitroalkane tsa mantlha.
Kotsi	Ntho e halefisang e ka bakang kotsi e mpe ea mahlo;E ka etsa hore letlalo le utloe bohloko;E chefo haholo ka ho hema
Ho chesa le ho phatloha	E tukang mollo
Mekhoa ea ho Hloekisa	Qhibiliha ester ka ho futhumatsa ho ~ 35o, 'me u e tšele ka har'a vacuum.Haeba IR le NMR (1810m 1765 cm-1 , ho CCl4 1.50 singlet) li fana ka maikutlo a hore ha li hloeke haholo, joale li hlatsoe ka tekanyo e lekanang ea H2O e nang le citric acid ho etsa hore lesela le nang le metsi le be le asiti hanyenyane, bokella lesela la manyolo le le omisa holim'a anhydrous MgSO4. 'me u e tšele ka har'a vacuum.[Mopapa le ba bang.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] E HLAHANG.