Asiti ea L-Malic

Tlhaloso e Khutšoanyane:

Lebitso la Sehlahisoa:Asiti ea L-Malic

Mantsoe a tšoanang:L-(-)-Malic acid, CP;Butanedioic acid, 2-hydroxy-, (2S)-;pinguosuan;Butanedioicacid,hydroxy-,(S)-;hydroxy-,(S) -Butanedioicacid;l-(ii) -malicacid;L-Gydroxybutanedioicacid;L-Mailcacid

CAS:97-67-6

MF:C4H6O5

MW:134.09

EINECS:202-601-5

Lihlopha tsa lihlahisoa:Li-extracts tsa semela;Aliphatics;MalicAcidSeries;Carboxylic Acids (Chiral);Chiral chemicals;Chiral Reagents;Lijo le EKETSEHILENG;Chiral Building Blocks;bakeng sa Tharollo ea Base;Optical Resolution;Synthetic Organic Chemistry;Sehlopha sa lijo le acidulant;Imidazoles Acculation;Imidazoles; bc0001

Mol File:97-67-6.mol

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Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Malic acid Chemical Properties

Sebaka se qhibilihang	101-103 °C (hote.)
alpha	-2 º (c=8.5, H2O)
Ntho e belang	167.16°C (khakanyo e boima)
tekano	1.60
khatello ea mouoane	0Pa ka 25 ℃
index ea refractive	-6.5 ° (C=10, Acetone)
FEMA	2655 \|ACID L-MALIC
Fp	220 °C
mocheso oa polokelo.	Boloka ka tlase ho +30°C.
ho qhibiliha	H₂O: 0.5 M ho 20 °C, e hlakileng, e se nang 'mala
sebopeho	Phofo
mmala	Bosoeu
Matla a Khoheli a khethehileng	1.595 (20/4℃)
PH	2.2 (10g/l, H2O, 20℃)
pka	(1) 3.46, (2) 5.10(ho 25℃)
tshebetso ya mahlo	[α]20/D 30±2°, c = 5.5% ka pyridine
Ho qhibiliha ha Metsi	qhibilihang
Merck	14,5707
JECFA Nomoro	619
BRN	1723541
InChIKey	BJEPYKJPYRNKOW-REOHCLBHSA-N
LogP	-1,68
Referense ea CAS DataBase	97-67-6(CAS DataBase Reference)
Referense ea Khemistri ea NIST	Butanedioic acid, hydroxy-, (s)-(97-67-6)
EPA Substance Registry System	Butanedioic acid, 2-hydroxy-, (2S)- (97-67-6)

Boitsebiso ba Tšireletseho

Likhoutu tsa Kotsi	Xi
Lipolelo tsa Kotsi	36/37/38
Lipolelo tsa Tšireletseho	26-36-37/39
WGK Jeremane	3
RTECS	ON7175000
TSCA	Ee
Khoutu ea HS	29181980

Tšebeliso ea Malic acid le Synthesis

Tlhaloso	L-Malic acid e batla e se na monko (ka linako tse ling ke monko o fokolang, oa acrid) ka tatso ea tart, e nang le asiti.Ha e na pungent.E ka lokisoa ka hydration ea asiti ea maleic;ka ho belisoa ho tsoa ho tsoekere.
Lintho tsa Lik'hemik'hale	L-Malic acid e batla e se na monko (ka linako tse ling ke monko o fokolang, oa acrid).Motsoako ona o na le tatso ea tart, acidic, nonpungent.
Lintho tsa Lik'hemik'hale	tharollo e se nang mebala e hlakileng
Ketsahalo	E etsahala ka lero la maple, apole, melon, papaya, biri, veine ea morara, cocoa, sake, kiwifruit le motso oa chicory.
Lisebelisoa	L-Malic acid e sebelisoa e le sehlomathiso sa lijo, Sekhetho se sirelletsang α-amino bakeng sa lintho tse tsoang ho amino acid.Synthon e fapaneng bakeng sa ho lokisoa ha metsoako ea chiral e akarelletsang κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, le phoslactomycin B.
Lisebelisoa	Ntho ea tlhaho ea tlhaho ke mofuta oa L o fumanoeng liapoleng le litholoana le limela tse ling tse ngata.Khetho ea α-amino e sireletsang reagent bakeng sa lihlahisoa tsa amino acid.Synthon e fapaneng bakeng sa ho lokisoa ha metsoako ea chiral e kenyelletsang κ-opioid rece
Lisebelisoa	E bohareng ka har'a motsoako oa lik'hemik'hale.Chelating le sesebelisoa sa ho boloka chelete.Monko o monate, se matlafatsang tatso le acidulant lijong.
Tlhaloso	ChEBI: Sebopeho se sebetsang sa malic acid se nang le (S) -configuration.
Tokisetso	L-Malic acid e ka lokisoa ka hydration ea asiti ea maleic;ka ho belisoa ho tsoa ho tsoekere.
Tlhaloso e Akaretsang	L-Malic acid ke organic acid e fumanehang ka har'a veine.E na le karolo ea bohlokoa ho botsitso ba veine ea microbiological.
Liketso tsa Biochem/physiol	L-Malic acid ke karolo ea metabolism ea cellular.Tšebeliso ea eona e amoheloa ka meriana.E na le thuso ho phekola ho se sebetse hantle ha sebete, e sebetsang khahlanong le hyper-ammonemia.E sebelisoa e le karolo ea infusion ea amino acid.L-Malic acid e boetse e sebetsa e le nanomedicine kalafong ea mathata a methapo ea kutlo.TCA (Krebs cycle) e bohareng le molekane oa malic acid aspartate shuttle.
Mekhoa ea ho Hloekisa	Crystallize S-malic acid (charcoal) ho tloha ethyl acetate/pet ether (b 55-56o), ho boloka mocheso o ka tlase ho 65o.Kapa e qhibilihe ka ho fetola likarolo tse leshome le metso e mehlano tsa anhydrous diethyl ether, decant, concentrate to one-third volume and crystallize it at 0o, ka makhetlo-khetlo ho ea kamehla melting point.[Beilstein 3 IV 1123]