N-Methyl-2-pyrrolidone

Tlhaloso e Khutšoanyane:

Lebitso la Sehlahisoa:N-Methyl-2-pyrrolidone

Mantsoe a tšoanang:M-PYROL(R);1-Methyl-2-pyrrolidinone(99.5%, HyDry, Water≤50 ppm (ka KF));1-Methyl-2-pyrrolidinone(99.5%, HyDry, e nang le sieve ea molek’hule, Metsi≤50) ppm (ka KF)); Moetsi oa N-Methyl-2-pyrrolidone;1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT ( ACS);1-Methyl-2-pyrrolidinone 872-50-4 NMP N-Methyl-2-pyrrolidinone;N-Methyl-2-pyrrolidinone 872-50-4 NMP;1-METHYL-2-PYRROLIDINONE

CAS:872-50-4

MF:C5H9NO

MW:99.13

EINECS:212-828-1

Lihlopha tsa lihlahisoa:NMP;Lisebelisuoa tse tala tsa lik'hemik'hale;UV/Vis); GC Headspace Solvents;GC Solvents;Solvents for GC applications;ACS le Reagent Grade Solvents;ACS Grade;ACS Grade Solvents;Carbon Steel Cans with NPT Threads;Heavy Metals;Solvents for LC- ICP-MS;Toxins (ntle le masala a chefo e bolaeang likokoanyana/lithethefatsi);Likopo;Tlhahlobo ea Lino;Lithibelo tsa Moaho;C4 ho isa ho C8;Chemical Synthesis;Lijo &;GC-MS Solvents;Heterocyclic Building Blocks;ICP-OES/-MS;Pyrrolidines; Li-reagents for Inorganic Trace Analysis;Lihlahisoa tsa Ts'ebetso ea Metal Speciation Analysis;Litlhapi tsa Tlhahlobo ea Bokhabane (LC-ICP-MS);Spectroscopy;Trace Analysis Reagents &;Anhydrous;Products;Solvent Bottles;Amines;Heterocycles;Mescellaneous Reagents;Anhydrous Solvents;Anhydrous; Kopo;Matla a Mang;Libotlolo tsa Amber Glass;Lisebelisuoa tsa ho Hlahlobisisa;Tlhahlobo/Chromatography;CHROMASOLV Plus;Lisebelisuoa tsa Chromatography &;Electrolytes;HPLC &;HPLC Plus Kereiting ea Lintlafatso (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV;NOLV);Materials Products Sciences Lisebelisoa tsa Organic;Semi-Bulk Solvents;Solvent Bottles;Solvent Packaging Options;UHPLC Solvents (CHROMASOLV);NMR;Spectrophotometric Grade;Spectrophotometric Solvents;Spectroscopy Solvents (IR;Lijana tse Returnable;Libotlolo tsa Sure/Seal;Biovents;Biovents; ;Ehlile/Tiiso?Libotlolo;872-50-4;bc0001

Mol File:872-50-4.mol

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Lintho tsa Lik'hemik'hale tsa Pyrrolidone

Sebaka se qhibilihang	-24 °C (hote.)
Ntho e belang	202 °C (lit.) 81-82 °C/10 mmHg (hote.)
tekano	1.028 g/mL ho 25 °C (hote.)
boima ba mouoane	3.4 (khahlanong le moea)
khatello ea mouoane	0.29 mm Hg (20 °C)
index ea refractive	n20/D 1.479
Fp	187 °F
mocheso oa polokelo.	Boloka ho +5°C ho ea ho +30°C.
ho qhibiliha	ethanol: miscible0.1ML/mL, e hlakileng, ha e na mebala (10%, v/v)
sebopeho	Mokelikeli
pka	-0.41±0.20(E boletsoeng esale pele)
mmala	≤20(APHA)
PH	8.5-10.0 (100g/l, H2O, 20℃)
Monko o monate	Monko o fokolang oa amine
PH Range	7.7 - 8.0
moeli oa ho phatloha	1.3-9.5%(V)
Ho qhibiliha ha Metsi	>=10 g/100 mL ka 20 ºC
E hloahloa	Hygroscopic
λmax	283nm(MeOH)(lit.)
Merck	14,6117
BRN	106420
Botsitso:	E tsitsitse, empa e bola ha e pepesehetse khanya.E tukang.Ha e lumellane le mahlahana a matla a oxidizing, li-acids tse matla, li-agent tse fokotsang, metheo.
InChIKey	SECXISVLQFMRJM-UHFFFAOYSA-N
LogP	-0.46 ho 25 ℃
Referense ea CAS DataBase	872-50-4(CAS DataBase Reference)
Referense ea Khemistri ea NIST	2-Pyrrolidinone, 1-methyl-(872-50-4)
EPA Substance Registry System	N-Methyl-2-pyrrolidone (872-50-4)

Boitsebiso ba Tšireletseho

Likhoutu tsa Kotsi	T, Xi
Lipolelo tsa Kotsi	45-65-36/38-36/37/38-61-10-46
Lipolelo tsa Tšireletseho	41-45-53-62-26
WGK Jeremane	1
RTECS	UY5790000
F	3-8-10
Autoignition Mocheso	518 °F
TSCA	Y
Khoutu ea HS	2933199090
Lintlha tsa Lintho Tse Kotsi	872-50-4(Boitsebiso ba Lintho Tse Kotsi)
Chefo	LD50 ka molomo ho Mmutla: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg

Tšebeliso ea Pyrrolidone le Synthesis

Lintho tsa Lik'hemik'hale	N-Methyl-2-pyrrolidone ke mokelikeli o pepeneneng o mosehla o se nang 'mala o nang le monko o fokolang oa ammonia.N-Methyl-2-pyrrolidone e kopane ka ho feletseng le metsi.E qhibiliha haholo ka har'a lino tse tahang, li-ketone tse tlase, ether, ethyl acetate, chloroform le benzene 'me e qhibiliha ka mokhoa o itekanetseng ho aliphatic hydrocarbons.N-Methyl-2-pyrrolidone e na le hygroscopic ka matla, e tsitsitse ka lik'hemik'hale, ha e senya ho ea ho carbon steel le aluminium, 'me e senya hanyenyane ho koporo.E na le sekhomaretsi se tlaase, lik'hemik'hale tse matla le botsitso ba mocheso, polarity e phahameng, le ho fokotseha ho tlaase.Sehlahisoa sena se chefo hanyenyane, 'me moeli oa eona o lumelletsoeng oa mahloriso moeeng ke 100ppm. N-Methyl-2-pyrrolidone ke solvent e sebelisoang liindastering le mekhoa e sa tšoaneng, e kang ho tlosa pente le ho roala, ho sebetsa ha petrochemical, liphahlo tsa polasetiki tsa boenjiniere, lik'hemik'hale tsa temo, ho hloekisa elektronike le ho hloekisa indasteri / malapeng.
Lisebelisoa	N-Methyl-2-pyrrolidone (NMP) ke polar aprotic solvent e nang le melemo ea chefo e tlaase, ntlha e belang e phahameng, solvency e ikhethang, khetho e matla le botsitso bo botle.E sebelisoa haholo ho hloekisa monko o monate oa hydrocarbon, acetylene, olefin le diolefin. E sebelisoa ho hloekisa liindasteri, 'me e sebetsa e le solvent bakeng sa tlhahiso ea chefo e bolaeang likokonyana, lipolasetiki tsa boenjiniere, liaparo, likhoele tsa maiketsetso le li-circuits tse kopaneng. E ka boela ea sebelisoa e le sehloekisi sa indasteri, dispersant, dae, lubricant le antifreeze. N-Methyl-2-pyrrolidone ke solvent e babatsehang, e sebelisoang haholo ho ntša aromatics, ho hloekisa oli, ho matlafatsa acetylene, karohano ea butadiene le synthesis gas desulfurization. E sebelisoa ho hloekisoa ha khase, ho hloekisa oli, ho tlotsa antifreeze ea oli, ho ntšoa ha olefin, le joalo ka solvent bakeng sa polymerization ea boenjiniere e sa keneng. E ka sebelisoa ho chefo ea herbicide, ho hloekisa lisebelisoa tsa ho kenya letsoho, lisebelisoa tse nepahetseng tsa indasteri ea semiconductor le liboto tsa potoloho, ho sebelisa mosi oa PVC hape, joalo ka sesepa, tlatsetso ea dae le moemeli ea hasaneng. E sebelisoa ho li-mediums bakeng sa karabelo ea polymerization joalo ka polasetiki ea boenjiniere le fiber ea aramid. N-Methyl-2-pyrrolidone e sebelisoa e le polyvinylidene fluoride solvent le electrode e thusang libeteri tsa lithium ion. boemo bo phahameng ba bohloeki bakeng sa ho lemoha ICP-MS. Bakeng sa peptide synthesis.
chefo	Oral (mus)LD50:5130 mg/kg;Oral (rat)LD50:3914 mg/kg;Dermal (rbt)LD50:8000 mg/kg.
Ho Lahla Litšila	Sheba melao ea naha, ea lehae kapa ea naha bakeng sa ho lahloa ka nepo.Ho lahloa ho tlameha ho etsoa ho latela melaoana ea semmuso.Metsi, ha ho hlokahala ka lisebelisoa tsa ho hloekisa.
polokelo	N-Methyl-2-pyrrolidone ke hygroscopic (e nka mongobo) empa e tsitsitse tlas'a maemo a tloaelehileng.E tla itšoara ka mabifi ka li-oxidizer tse matla tse kang hydrogen peroxide, nitric acid, sulfuric acid, joalo-joalo Lihlahisoa tse ka sehloohong tsa ho bola li hlahisa carbon monoxide le mosi oa nitrogen oxide.Ho pepeseha ho feteletseng kapa ho qhalla ha metsi ho lokela ho qojoa e le mokhoa o motle.Khamphani ea Lyondell Chemical e khothaletsa ho roala liatlana tsa butyl ha u sebelisa N-Methyl-2-pyrrolidone.N-Methyl-2-pyrrolidone e lokela ho bolokoa ka har'a tšepe e hloekileng, e nang le phenolic-lined bonolo kapa meropa ea alloy.Teflon®1 le Kalrez®1 li bontšitsoe e le lisebelisoa tse loketseng tsa gasket.Ka kopo, hlahloba MSDS pele u sebetsana.
Tlhaloso	N-Methyl-2-pyrrolidone ke motsoako oa aprotic o nang le mefuta e mengata ea lisebelisoa: ts'ebetso ea petrochemical, ho roala holim'a metsi, lidae le li-pigments, lik'hemik'hale tsa ho hloekisa indasteri le malapeng, le lihlahisoa tsa temo le tsa meriana.Haholo-holo ke ntho e halefisang, empa hape e bakile linyeoe tse 'maloa tsa ho kopana le dermatitis k'hamphaning e nyenyane ea electrotechnical.
Lintho tsa Lik'hemik'hale	N-Methyl-2-pyrrolidone ke mokelikeli o mosehla o se nang 'mala kapa o bobebe o nang le monko oa amine.E ka ba le liphetoho tse ngata tsa lik'hemik'hale le hoja e amoheloa e le solvent e tsitsitseng.E hanana le hydrolysis tlas'a maemo a sa nke lehlakore, empa asiti e matla kapa kalafo ea motheo e fella ka ho buleha ha selikalikoe ho 4-methyl aminobutyric acid.N-Methyl-2-pyrrolidone e ka fokotsoa ho 1-methyl pyrrolidine ka borohydride.Kalafo e nang le chlorinating agents e fella ka ho thehoa ha amide, e bohareng e ka kenang sebaka se eketsehileng, ha phekolo ea amyl nitrate e hlahisa nitrate.Li-olefine li ka kenyelletsoa sebakeng sa 3 ka phekolo ea pele ka li-oxalic esters, ebe li-aldehyes tse loketseng (Hort le Anderson 1982).
Lisebelisoa	N-Methyl-2-pyrrolidone ke motsoako oa polar o sebelisoang ho chemistry ea organic le polymer chemistry.Lisebelisoa tse kholo li kenyelletsa ho hlaphoheloa le ho hloekisoa ha acetylenes, olefin, le diolefin, tlhoekiso ea khase, le ho ntšoa ha aromatics ho tsoa ho li-feedstocks.N-Methyl-2-pyrrolidone ke solvent ea indasteri e nang le mefuta e mengata.NMP hajoale e amohetsoe ho sebelisoa feela litlhare tsa bongaka ba liphoofolo.Boikemisetso ba sebopeho le metabolism ea NMP ho rat bo tla thusa ho utloisisa chefo ea k'hemik'hale ena e sa tloaelehang eo motho a ka bang le eona ka bongata bo ntseng bo eketseha.
Lisebelisoa	Solvent bakeng sa li-resin tse phahameng tsa mocheso;ts'ebetso ea petrochemical, indastering ea tlhahiso ea li-microelectronics, lidae le li-pigments, metsoako ea ho hloekisa ea indasteri le ea malapeng;mekhoa ea temo le ea meriana
Lisebelisoa	N-Methyl-2-pyrrolidone, e na le thuso bakeng sa spectrophotometry, chromatography le ICP-MS ho lemoha.
Tlhaloso	ChEBI: Setho sa sehlopha sa pyrrolidine-2-one e leng pyrrolidin-2-one eo hydrogen e kopantsoeng le naetrojene e nkeloang sebaka ke sehlopha sa methyl.
Mekhoa ea Tlhahiso	N-Methyl-2-pyrrolidone e entsoe ke karabelo ea buytrolactone ka methylamine (Hawley 1977).Mekhoa e meng e kenyelletsa ho lokisetsa ka hydrogenation ea tharollo ea maleic kapa succinic acid ka methylamine (Hort le Anderson 1982).Baetsi ba k'hemik'hale ena ba kenyelletsa Lachat Chemical, Inc, Mequon, Wisconsin le GAF Corporation, Covert City, California.
Litšupiso tsa Synthesis	Mangolo a Tetrahedron, 24, leq.1323, 1983DOI: 10.1016/S0040-4039(00)81646-9
Tlhaloso e Akaretsang	N-Methyl-2-Pyrrolidone (NMP) ke solvent e matla, e nang le aprotic e nang le solvency e phahameng, le ho fokotseha ha tlaase.Mokelikeli ona o se nang 'mala, o belang o phahameng, o khanyang o phahameng le mokelikeli o tlaase oa mouoane o na le monko o bobebe o kang oa amine.NMP e na le botsitso bo phahameng ba lik'hemik'hale le mocheso 'me e kopane ka ho feletseng le metsi ka mocheso o mong le o mong.NMP e ka sebetsa e le co-solvent ka metsi, joala, glycol ethers, ketone, le li-hydrocarbon tse nkhang hamonate / chlorinated.NMP ka bobeli e sebelisoa hape ka distillation le ho senyeha habonolo.NMP ha e fumanehe lenaneng la Hazardous Air Pollutants (HAPs) la 1990 Clean Air Act Amendment.
Maikutlo a Moea le Metsi	E qhibilihang ka metsing.
Boemo ba Reactivity	Amine ena ke setsi sa lik'hemik'hale se bobebe haholo.N-Methyl-2-pyrrolidone e atisa ho fokotsa li-acids ho etsa letsoai le metsi.Palo ea mocheso o fetohang ka molek'hule oa amine ka ho se nke lehlakore o itšetlehile haholo ka matla a amine e le motheo.Li-amine li ka ’na tsa se lumellane le li-isocyanate, li-halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, le acid halides.Hydrojene e tukang ea gaseous e hlahisoa ke li-amine hammoho le li-reduction agents tse matla, tse kang li-hydrides.
Kotsi	Letlalo le matla le ho hlohlona mahlong.Moeli o phatlohang-ke 2.2–12.2%.
Kotsi ea Bophelo bo Botle	Ho hema mouoane o chesang ho ka halefisa nko le 'metso.Ho ja ho baka ho teneha ha molomo le mala.Ho kopana le mahlo ho baka ho teneha.Ho kopana ha letlalo ka makhetlo a mangata le nako e telele ho hlahisa ho teneha ha nakoana, ho sa feleng.
Kotsi ea Mollo	Likotsi Tse Khethehileng tsa Lihlahisoa tsa Mocheso: Li-toxic oxides tsa nitrogen li ka etsoa mollong.
Ho chesa le ho phatloha	E sa cheng
Lisebelisoa tsa indasteri	1) N-Methyl-2-pyrrolidone e sebelisoa e le motsoako o akaretsang oa dipolar aprotic, o tsitsitseng le o sa sebetseng; 2) bakeng sa ho ntšoa ha li-hydrocarbon tse nkhang hamonate ka oli e tlotsang; 3) bakeng sa ho tlosoa ha carbon dioxide ka lijenereithara tsa ammonia; 4) e le solvent bakeng sa karabelo ea polymerization le li-polymers; 5) e le seaparo sa pente; 6) bakeng sa metsoako ea chefo e bolaeang likokoanyana (USEPA 1985). Litšebeliso tse ling tseo e seng tsa indasteri tsa N-Methyl-2-pyrrolidone li thehiloe holim'a thepa ea eona e le motsoako o arolang o loketseng lithuto tsa lik'hemik'hale tsa motlakase le tsa 'mele (Langan le Salman 1987).Lisebelisoa tsa meriana li sebelisa thepa ea N-Methyl-2-pyrrolidone e le se matlafatsang ho phunyeletsa bakeng sa phetiso e potlakileng ea lintho ka letlalo (Kydoniieus 1987; Barry and Bennett 1987; Akhter and Barry 1987).N-Methyl-2-pyrrolidone e amohetsoe e le solvent bakeng sa kopo ea slimicide ho thepa ea ho paka lijo (USDA 1986).
Ikopanye le lintho tse phelisang hantle	N-Methyl-2-pyrrolidone ke motsoako oa aprotic o nang le mefuta e mengata ea lisebelisoa: ts'ebetso ea petrochemical, ho roala holim'a metsi, lidae le li-pigments, lik'hemik'hale tsa ho hloekisa indasteri le malapeng, le lihlahisoa tsa temo le tsa meriana.Haholo-holo ke ntho e tenang, empa e ka baka dermatitis e matla ka lebaka la ho kopana nako e telele.
Boemo ba Polokeho	Chefo ka tsela ea methapo.E na le chefo e itekanetseng ka ho noa le litsela tsa intraperitoneal.Chefo e nyane ka ho kopana le letlalo.Teratogen ea liteko.Liphello tsa teko ea ho ikatisa.Litaba tsa phetoho li tlalehiloe.E chaba ha e pepeselitsoe mocheso, lelakabe le bulehileng, kapa li-oxidizer tse matla.Ho loantša mollo, sebelisa foam, CO2, lik'hemik'hale tse omeletseng.Ha e chesa ho bola e ntša mosi o chefo oa NOx.
Lefu la kankere	Likhoto li ne li pepesehetse mouoane oa N-Methyl-2-pyrrolidone ho 0, 0.04, kapa 0.4 mg / L bakeng sa 6 h / letsatsi, matsatsi a 5 / beke bakeng sa lilemo tsa 2. Litoeba tsa banna ho 0.4 mg / L li bontšitse ho fokotseha hanyenyane boima ba 'mele.Ha ho liphello tse chefo kapa tsa kankere tse khutsufatsang bophelo tse ileng tsa bonoa ho likhoto tse pepesehileng lilemo tsa 2 ho 0.04 kapa 0.4mg / L ea N-Methyl-2-pyrrolidone.Ka tsela ea dermal, sehlopha sa litoeba tsa 32 se ile sa fumana tekanyo ea ho qala ea 25mg ea N-Methyl-2-pyrrolidone e ileng ea latela libeke tsa 2 hamorao ka likopo tsa motlatsi oa tumor phorbol myristate acetate, ka makhetlo a mararo ka beke, bakeng sa libeke tse fetang 25.Dimethylcarbamoyl chloride le dimethylbenzanthracene di sebeditse e le ditaolo tse ntle.Le hoja sehlopha sa N-Methyl-2-pyrrolidone se ne se e-na le lihlahala tse tharo tsa letlalo, karabelo ena e ne e sa nkoa e le ea bohlokoa ha e bapisoa le ea taolo e ntle.
Mokhoa oa metabolic	Likhoto li tsamaisoa ka seea-le-moea se bitsoang N-methyl-2-pyrrolidinone (NMP), 'me tsela e kholo ea ho ntša likhoto ke ka moroto.Metabolite e kholo, e emelang 70-75% ea tekanyo e laoloang, ke 4-(methylamino) butenoic acid.Sehlahisoa sena se sa tsitsang se sa tsitsang se ka thehoa ho tloha ho felisoa ha metsi, 'me sehlopha sa hydroxyl se ka ba teng ho metabolite pele ho acid hydrolysis.
Metabolism	Litoeba tsa banna ba Sprague-Dawley li ile tsa fuoa ente e le 'ngoe ea intraperitoneal (45 mg / kg) ea radiolabeled 1 -methyl-2-pyrrolidone.Maemo a plasma a radioactivity le metsoako a ile a behoa leihlo ka lihora tse tšeletseng 'me liphetho li fana ka maikutlo a mohato oa kabo e potlakileng o ileng oa lateloa ke mohato o liehang oa ho felisa.Palo e kholo ea leibole e ile ea ntšoa ka har'a moroto nakong ea lihora tse 12 'me e ne e le karolo ea 75% ea tekanyo e ngotsoeng.Lihora tse mashome a mabeli a metso e mene ka mor'a ho noa, ho ntšoa ha moroto (moroto) ho ne ho ka ba 80% ea lethal dose.Ka bobeli mefuta e ngotsoeng ka ring-le methyl e ile ea sebelisoa, hammoho le ka bobeli [¹⁴C] - le [3H] -e ngotsoeng l-methyl-2-pyrrolidone.Likarolo tsa pele tse ngolisitsoeng li ile tsa bolokoa nakong ea lihora tse 6 tsa pele ka mor'a tekanyetso.Kamora lihora tse 6, ho ile ha fumanoa hore sebete le mala li na le pokello e phahameng ka ho fetisisa ea radioactivity, hoo e ka bang 2-4% ea lethal dose.Radioactivity e nyenyane e ile ea hlokomeloa ka bile kapa moea o phefumolohang.Ts'ebetso e phahameng ea chromatography ea moroto e bonts'a boteng ba metabolite e le 'ngoe e kholo le tse peli tse nyane.Metabolite e kholo (70-75% ea lethal dose la radioactive) e ile ea hlahlojoa ke mokelikeli oa chromatography-mass spectrometry le khase chromatography-mass spectrometry 'me ho ile ha etsoa tlhahiso ea hore e be 3- kapa 5-hydroxy-l-methyl-2-pyrrolidone (Wells. 1987).
Mekhoa ea ho Hloekisa	Omisa pyrrolidone ka ho tlosa metsi joalo ka *benzene azeotrope.Distil ka fractionally ho 10 torr ka kholomo ea 100-cm e tletse ka liheli tsa khalase.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] Hydrochloride e na le m 86-88o (ho tloha EtOH kapa Me2CO/EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.]