Lihlahisoa
Pyrimidine-2,4 (1H,3H) -dione
Litlhaloso tse tšoanang: Uracil
Thepa ea Lik'hemik'hale ea Pyrimidine-2,4 (1H,3H) -Dione
● Ponahalo/Mmala: phofo e tšoeu
● Khatello ea Mouoane: 2.27E-08mmHg ho 25°C
● Sebaka se qhibilihang:>300 °C(lit.)
● Refractive Index: 1.501
● Sebaka se belang: 440.5 ° C ho 760 mmHg
● PKA:9.45(ho 25℃)
● Flash Point: 220.2oC
● PSA:65.72000
● Boima ba 'mele: 1.322 g/cm3
● LogP: -0.93680
● Mocheso oa ho Boloka.: +15C ho ea ho +30C
● Solubility.: Aqueous Acid (Hanyenyane), DMSO (Hanyenyane, E futhumetse, e Sonicated), Methanol (Hanyenyane,
● Ho qhibiliha ha Metsi.: E qhibiliha ka metsing a chesang
● XLogP3:-1.1
● Hydrogen Bond Donor Count:2
● Hydrogen Bond Accepter Palo:2
● Rotatable Bond Count:0
● Hantle 'Misa: 112.027277375
● Palo ea Athomo e Boima:8
● Ho rarahana:161
Boitsebiso bo Boreleli
● Litšoantšo:
Xi
● Likhoutu tsa Kotsi:Xi
● Lipolelo tsa Tšireletseho: 22-24/25
E molemo
Lihlopha tsa Lik'hemik'hale:Li-Biological Agents -> Nucleic Acids le Derivatives
Canonical SMILES:C1=CNC(=O)NC1=O
Liteko tsa Haufinyane tsa Clinical:Thuto ea 0.1% Uracil Topical Cream (UTC) bakeng sa Thibelo ea Lefu la Hand-Foot Syndrome
Liteko tsa morao-rao tsa Kliniki tsa EU:Onderzoek naar de farmacokinetiek van uracil na orale toediening bij pati?nten met colorectaal carcinoom.
Haufinyane tjena NIPH Clinical Trials: Teko ea mohato oa II ea mafura a uracil bakeng sa ho thibela lefu la capecitabine le bakoang ke letsoho la maoto (HFS):.
Lisebelisoa:Bakeng sa lipatlisiso tsa biochemical, motsoako oa lithethefatsi; e sebelisoa e le li-intermediate tsa meriana, hape e sebelisoa ho organic synthesis ea naetrojene ho li-nucleosides tsa RNA. antineoplastic Lipatlisisong tsa biochemical. Uracil (Lamivudine EP Impurity F) ke motheo oa naetrojene ho li-nucleosides tsa RNA.
Tlhaloso:Uracil ke setsi sa pyrimidine le karolo ea mantlha ea RNA moo e tlamang ho adenine ka li-hydrogen bond. E fetoleloa ho nucleoside uridine ka ho eketsoa ha karolo ea ribose, ebe ho nucleotide uridine monophosphate ka ho eketsoa ha sehlopha sa phosphate.
Kenyelletso e Feletseng
Uracil ke motsoako oa manyolo oo e leng oa lelapa la pyrimidine derivatives. Ke molek'hule e nkhang hamonate ea heterocyclic e nang le selikalikoe sa pyrimidine se nang le liathomo tse peli tsa boahelani tsa naetrojene. Uracil e na le foromo ea lik'hemik'hale C4H4N2O2 le boima ba molek'hule ea 112.09 g/mol.
Uracil ke e 'ngoe ea li-nucleobases tse' nè tse fumanoang liphatseng tsa lefutso tsa RNA (ribonucleic acid). E bapala karolo ea bohlokoa ho protheine synthesis le liphatsa tsa lefutso. Ho RNA, lipara tsa uracil tse nang le adenine ka hydrogen bonding, li etsa li-bond tse peli tsa hydrogen, 'me motheo ona oa ho kopanya o thusa ho kenyelletsa lintlha tsa lefutso.
Uracil e ka boela ea fumanoa ho limolek'hule tse ling tsa bohlokoa tsa likokoana-hloko. Ka mohlala, ke karolo ea bohlokoa ea molek'hule e tsamaisang matla e bitsoang ATP (adenosine triphosphate). Li-derivatives tsa Uracil, tse kang 5-fluorouracil, li 'nile tsa sebelisoa e le li-anticancer agents ka lebaka la bokhoni ba tsona ba ho kena-kenana le ho ikatisa ha DNA le karohano ea lisele.
Ntle le bohlokoa ba eona ba tlhaho, uracil e na le lisebelisoa tse fapaneng tsa lik'hemik'hale le tsa indasteri. E sebelisoa e le sesebelisoa sa ho qala bakeng sa ho kopanya meriana, li-agrochemicals le dae. Li-derivatives tsa Uracil li boetse li sebelisoa ha ho etsoa li-herbicides le fungicides. Ho feta moo, uracil e ka sebelisoa e le letšoao ho k'hemistri ea tlhahlobo le e le sesebelisoa lipatlisisong tsa baeloji ea limolek'hule.
Uracil ke kristale e tšoeu e tiileng e qhibilihang hanyenyane metsing. E tsitsitse tlas'a maemo a tloaelehileng empa e ka ba le liphetoho tsa lik'hemik'hale, tse kang oxidation le substitution reactions, tlas'a maemo a itseng. Motsoako o na le sebaka se qhibilihang sa 335-338°C le ntlha e belang ea 351-357°C.
Ka kakaretso, uracil ke karolo ea bohlokoa lits'ebetsong tsa baeloji ea RNA mme e na le ts'ebeliso ea bohlokoa indastering ea baeloji le ea lik'hemik'hale.
Kopo
Uracil e na le lits'ebetso tse 'maloa likarolong tse fapaneng, ho kenyelletsa:
Indasteri ea Litlhare:Uracil le lihlahisoa tsa eona li 'nile tsa sebelisoa ho hlahisa lithethefatsi bakeng sa merero e sa tšoaneng. Mohlala, 5-fluorouracil ke setlhare sa chemotherapy se sebelisoang hangata ho alafa mefuta e itseng ea mofetše. Lithethefatsi tse thibelang likokoana-hloko tse thehiloeng ho Uracil, tse kang idoxuridine le trifluridine, li sebelisoa ho phekola tšoaetso ea mahlo a kokoana-hloko.
Temo:Li-derivatives tsa Uracil li sebelisoa ha ho etsoa li-herbicides le fungicides. Metsoako ena e thusa ho laola ho hōla ha mofoka le ho sireletsa lijalo khahlanong le mafu a fungal.
Analytical Chemistry:Hangata Uracil e sebelisoa e le letšoao la chromatographic kapa maemo a ka hare ho mekhoa ea ho hlahloba k'hemistri. E ka sebelisoa e le motsoako oa litšupiso ho fumana nako ea ho boloka le ho lekanya metsoako e meng ka sampuli.
Patlisiso ea Biology ea Limolek'hule:Uracil e sebelisoa mekhoeng e fapaneng ea baeloji ea limolek'hule, joalo ka polymerase chain reaction (PCR), tatellano ea DNA, le mutagenesis e tsamaisoang ke sebaka. E sebetsa e le template bakeng sa motsoako oa DNA kapa e le karolo ea ho theha liphetoho tse itseng ka tatellano ea DNA.
Indasteri ea Lijo:Uracil e sebelisoa ka linako tse ling e le se matlafatsang tatso indastering ea lijo, haholo tlhahisong ea lijo tse phehiloeng le lino tse tahang.
Litlolo:Li-derivatives tsa Uracil li sebelisoa lihlahisoa tsa litlolo bakeng sa thepa ea tsona ea mongobo le e thobang letlalo. Li ka thusa ho ntlafatsa hydration ea letlalo le ho sireletsa khahlanong le khatello ea tikoloho.
Lipatlisiso le Ntlafatso:Uracil e boetse e sebelisoa lipatlisisong tsa biochemical le tsa meriana e le reagent kapa e bohareng bakeng sa ho kopanya metsoako e meng ka ts'ebetso ea likokoana-hloko kapa ho ithuta nucleic acid metabolism.
Mefuta e mengata ea ts'ebeliso ea Uracil e bonts'a bohlokoa ba eona mafapheng a kang bongaka, temo, k'hemistri le biotechnology. Bafuputsi ba ntse ba tsoela pele ho fumana mekhoa e mecha ea ho sebelisa thepa ea eona bakeng sa tsoelo-pele e eketsehileng libakeng tsena.
